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KMID : 0191120100250010110
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Journal of Korean Medical Science
2010 Volume.25 No. 1 p.110 ~ p.116
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GnRH Agonist Therapy to Protect Ovarian Function in Young Korean Breast Cancer Patients
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Park Hyun-Jung
Koo Young-Ah
Im Young-Hyuck
Yoon Byung-Koo
Choi Doo-Seok
Koo Young-Ah
Im Young-Hyuck
Yoon Byung-Koo
Choi Doo-Seok
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Abstract
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The increased survival of patients with breast cancer has given rise to other problems associated with the complications of chemotherapy. One major complication is premature ovarian failure, an especially harmful outcome for women of reproductive age. This study was performed to evaluate the efficacy of GnRH agonist (GnRHa) treatment on protecting ovarian function in young breast cancer patients (30.59±5.1 yr) receiving chemotherapy after surgery. Twenty-two women were enrolled and given subcutaneous injections of leuprolide acetate (3.75 mg) every 4 weeks during chemotherapy. Follow-up laboratory tests (luteinizing hormone [LH], follicle stimulating hormone [FSH], and estradiol) were performed 1, 3, and 6 months after chemotherapy. Menstruation patterns and clinical symptoms were followed up for a mean duration of 35.6±1.7 months. FSH and LH levels were normal in all patients 6 months after completing chemotherapy (8.0±5.3, 4.4±2.7 mIU/mL, respectively). During follow-up, none of the patients complained of menopausal symptoms and 81.8% experienced recovery of menstruation. This report is the first trial of GnRHa as a treatment modality to protect ovarian function during adjuvant chemotherapy in young Korean breast cancer patients.
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KEYWORD
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Ovarian function, Drug Therapy, GnRH agonist, Breast Neoplasms
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